Products & Services

Parabon Essemblix^™
Drug Development Platform

Designing drugs, one molecule at a time

With Essemblix, we design and produce functional DNA-based nanostructures for ourselves and our customers.

Essemblix's "plug-and-play" molecular engineering makes it possible to create an enormous variety of multi-functional compounds. Functional subcomponents of Essemblix compounds include:

• cell-specific targeting agents
• therapeutic payloads, such as small molecules or siRNA
• imaging tracers; and,
• precisely patterned antigens for eliciting strong immune response.

The above stages of development for an example nanocarrier, P-230, show that Essemblix can facilitate concept to compound efficiently and affordably.

Our Pharmaceutical Pipeline

P24RDN is designed for the treatment of GBM. Preclinical studies have demonstrated it to be safe and effective, and significantly increases survival in murine models hosting intracranial human glioma tumors.

PJ-01, which is being developed through a partnership with Janssen Pharmaceuticals, is designed for the treatment of prostate cancer. Preclinical studies are underway.

Services

Using Essemblix, we can design and produce custom nanostructures to satisfy specific customer requirements. Example Essemblix applications include cell/tissue recognition, cell specific transfection, and targeted drug delivery.

Parabon Snapshot^®
Advanced DNA Analysis Service

Redefining the field of DNA Forensics

Send us a human DNA sample and, using Snapshot, we will produce a forensic profile containing predictions about the physical traits of its source.

A Snapshot "composite profile" that combines several trait predictions into a unified facial representation

Because some traits are partially determined by environmental factors and not DNA alone, Snapshot trait predictions are presented with a corresponding measure of confidence, which reflects the degree to which such factors influence each particular trait. Traits, such as eye color, that are highly heritable (i.e., are not greatly affected by environmental factors) are predicted with higher accuracy and confidence than those that have lower heritability.

The set of traits currently provided by Snapshot includes:

Parabon has outfitted Snapshot with a unique ability to predict face morphology and couple it with other related trait predictions, giving Snapshot the ability to produce a "digital mugshot" of an individual corresponding to a given DNA sample.

Learn more about Snapshot